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KMID : 0043320090320060841
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Archives of Pharmacal Research
2009 Volume.32 No. 6 p.841 ~ p.844
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A New Cytotoxic Spiroketal from the Myxobacterium Sorangium cellulosum
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Ahn Jong-Woong
Kwak Jong-Hwan
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Abstract
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A new spiroketal, spirodienal B (1), was isolated from culture extracts of S. cellulosum. Its structure was elucidated by spectroscopic analysis. In addition to 1, the strain produced a second, closely related antibiotic, spirodienal. Both compounds demonstrated potent cytotoxicity against human tumor cells. Against human tumor cells such as HCT-15, the activity of 1 was more than 4000 times stronger than that of doxorubicin in terms of IC50.
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KEYWORD
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Sorangium cellulosum, Myxobacteria, Spiroketal, Cytotoxicity
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